Overview
Modified cellulose, specifically carboxymethylcellulose (CMC), is a low-fermentability soluble fiber used as a dietary supplement for managing fecal incontinence (FI), particularly in individuals with loose or liquid stool. In a randomized clinical trial, CMC supplementation did not significantly improve FI frequency compared to placebo, and was associated with lower in vitro fermentation by colonic bacteria compared to other fibers like gum arabic and psyllium [1][2]. This low fermentability may limit the production of short-chain fatty acids and reduce beneficial effects on gut health and stool consistency. While generally well-tolerated, CMC appears less effective than more fermentable fibers for improving bowel control and colonic metabolism.
Dosage Guide
Therapeutic Doses
For treatment of specific conditions
Clinical Notes
- CMC is poorly fermented by gut microbiota, which may limit its effectiveness for improving stool consistency and gut health.
- No significant improvement in fecal incontinence symptoms was observed in clinical trials compared to placebo.
- Generally recognized as safe (GRAS) for use in food, but limited evidence supports therapeutic benefit as a fiber supplement.
Research
Carboxymethylcellulose (CMC) did not significantly reduce fecal incontinence frequency compared to placebo in a 14-day trial.
In vitro fermentation of CMC by human colonic bacteria was lower than gum arabic or psyllium, indicating low fermentability.
Products Containing Modified Cellulose(0 reports)
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