Cold Pressed Pumpkin Seed Oil 3000MG by Carlyle is formulated to support prostate and urinary health, leveraging the well-documented bioactive properties of pumpkin seed oil. The 3,000 mg dose per serving aligns with clinical studies investigating pumpkin seed oil’s efficacy in managing mild-to-moderate lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). Research indicates that pumpkin seed oil may improve urinary flow, reduce nocturia, and decrease symptom severity, likely through anti-inflammatory, anti-proliferative, and phytoestrogenic mechanisms [1][2].
The cold-pressed extraction method preserves heat-sensitive compounds such as polyphenols and unsaturated fatty acids, enhancing the oil’s antioxidant and lipid-modulating potential. While not a pharmaceutical agent, this supplement fits within the growing category of evidence-supported phytotherapeutics for men’s health. Additional components—linoleic acid (1,200 mg) and oleic acid (480 mg)—are naturally present in the oil matrix and contribute to overall fatty acid balance, though they are not the primary drivers of the product’s intended benefits.
Quick Summary
All ingredient amounts are clearly disclosed with no proprietary blends, enabling full dose evaluation and transparency in formulation.
The primary ingredient, pumpkin seed oil, is dosed at 3,000 mg—exceeding the clinical benchmark of 2,000 mg/day for LUTS and BPH—supporting high efficacy. Supporting fatty acids are sub-therapeutic but do not detract from the primary indication.
Cold-pressed pumpkin seed oil preserves heat-sensitive bioactives and is delivered in softgel form, enhancing lipid absorption. High-fat content supports endogenous uptake of fat-soluble compounds, earning a +10% bioavailability credit.
Generally safe with minimal adverse effects, though potential interactions with anticoagulants and theoretical hormonal effects warrant caution. No upper limit established, but high doses should be used judiciously in sensitive populations.
Suggested: 1 serving/day to reach clinical midpoint
Why Take This Product
Key Benefits
- Rich in Essential Fatty Acids: Provides 1,200 mg of linoleic acid (omega-6) and 480 mg of oleic acid (omega-9), contributing to improved fatty acid profiles and membrane integrity, with potential benefits for cardiovascular and metabolic function [9].
- May Support Metabolic Health: Dietary pumpkin seed supplementation has been shown to improve fatty acid status in clinical populations, including hemodialysis patients, suggesting systemic metabolic benefits [9].
- Potential Chemopreventive Properties: In vitro studies indicate pumpkin seed extracts inhibit proliferation and induce autophagy in prostate cancer cells, suggesting a role in prostate health maintenance, though human data are lacking [3].
Who Should Take This
Potential Side Effects
Ingredient Breakdown
The formulation centers on cold-pressed pumpkin seed oil as the primary active ingredient, with naturally occurring fatty acids—linoleic and oleic acid—present as supporting components. No synthetic additives or proprietary blends are indicated, allowing for transparent dose assessment.
Primary Ingredients
Pumpkin Seed Oil
Primary support for prostate and urinary health, rich in phytosterols and polyunsaturated fatty acids
Dose exceeds the clinical midpoint of 1,000 mg twice daily (2,000 mg/day), achieving 150% of the daily clinical target in a single serving. Cold-pressed form enhances bioavailability of heat-sensitive compounds.
Cold-pressed pumpkin seed oil is rich in phytosterols, linoleic acid, alpha-linolenic acid, and polyphenols. It has demonstrated clinical benefits in reducing lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH), likely through anti-inflammatory, anti-proliferative, and hormonal modulation mechanisms. Experimental studies also suggest chemopreventive potential in prostate cancer models [1][3].
Supporting Ingredients
There are 2 supporting ingredients.
Practical Recommendations
- Combine With Omega-3 Fatty Acids: To balance the omega-6 content (linoleic acid), consider co-supplementing with EPA/DHA to maintain a favorable n-6:n-3 ratio and reduce potential pro-inflammatory effects [8].
- Monitor For Drug Interactions: Exercise caution when using with anticoagulants due to vitamin E and unsaturated fat content; consult a healthcare provider if on blood thinners or managing hormone-sensitive conditions.
Is it Safe?
Pumpkin seed oil has a strong safety profile in clinical studies, with minimal adverse events reported. However, potential interactions with anticoagulants and theoretical hormonal effects warrant caution in specific populations. The absence of established upper limits supports moderate use, but long-term safety data remain limited.
Safety & Considerations
- Drug Interaction: Potential interaction with anticoagulants due to vitamin E and unsaturated fatty acid content; monitor for increased bleeding risk.
- Hormonal Effect: Phytosterol content may theoretically affect hormone-sensitive conditions; use with caution in individuals with prostate cancer or on hormone therapy.
- Pregnancy: Safety not established during pregnancy or breastfeeding; avoid unless advised by a healthcare provider.
The Science
The 3,000 mg dose of pumpkin seed oil meets clinical benchmarks for efficacy in managing LUTS and BPH, supported by randomized controlled trials. While supporting fatty acids are below therapeutic thresholds for standalone use, their presence enhances the oil’s overall bioactive profile without detracting from the primary indication.
Pumpkin seed extracts show clinical promise for treating lower urinary tract symptoms related to benign prostatic hyperplasia.
Pumpkin seed soft extract studied in 12-month RCTs shows potential for managing mild-to-moderate male LUTS.
Pumpkin seed extracts inhibit proliferation and induce autophagy in androgen-insensitive prostate cancer cells in vitro.
CLA supplementation in humans shows ambiguous effects on body composition and lipid profiles; some unfavorable changes like reduced HDL and increased lipoprotein(a) observed.
Meta-analysis shows CLA supplementation leads to modest but statistically significant weight loss in overweight/obese individuals over 6+ months.
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