SIDEGRA contains sildenafil, a potent prescription drug approved for the treatment of erectile dysfunction (ED), not a dietary or herbal supplement. Its mechanism involves selective inhibition of PDE5, leading to increased cyclic guanosine monophosphate (cGMP) levels and smooth muscle relaxation in the corpus cavernosum, facilitating penile erection in response to sexual stimulation. At 50 mg, the dose aligns with standard clinical initiation regimens for ED management.
However, the presence of sildenafil in products not regulated as pharmaceuticals raises serious safety concerns. Numerous studies have identified unlisted PDE5 inhibitors—including sildenafil and its structural analogues—in products marketed as 'herbal' or 'natural' sexual enhancers, often at unpredictable or excessive doses [1][2]. These findings highlight the risk of adulteration and underscore the importance of sourcing such medications only through legitimate, regulated channels.
Quick Summary
The formulation clearly lists the active ingredient and its exact dosage (50 mg sildenafil), with no proprietary blends or hidden components. Full transparency supports safe and informed use.
The 50 mg dose of sildenafil is within the clinically effective range (25–100 mg) established in multiple trials and represents the most commonly prescribed starting dose for ED treatment, offering reliable efficacy for most patients.
Sildenafil citrate is a well-absorbed pharmaceutical form with approximately 40% oral bioavailability and predictable pharmacokinetics. The 50 mg dose is clinically validated and widely used in approved medications.
While sildenafil is safe when used correctly under medical supervision, it carries serious risks including hypotension, priapism, and cardiovascular events—especially when combined with nitrates or in patients with unstable heart disease.
Why Take This Product
Key Benefits
- Improved Erectile Function: Clinical studies show that sildenafil significantly improves the ability to achieve and sustain erections in men with ED, with effects typically beginning within 30–60 minutes and lasting up to 4 hours.
- Enhanced Sexual Confidence: By supporting reliable erectile response during sexual stimulation, sildenafil can reduce performance anxiety and improve overall sexual satisfaction and quality of life.
- Well-Studied and Predictable Effects: With decades of clinical use and extensive research, sildenafil’s efficacy and pharmacokinetic profile are well understood, allowing for safe and effective dosing when used appropriately under medical guidance.
Who Should Take This
Potential Side Effects
Ingredient Breakdown
The sole active ingredient in SIDEGRA is sildenafil citrate, a synthetic pharmaceutical compound and not a nutritional or herbal substance. It is formulated for precise dosing and rapid absorption to ensure consistent clinical effects.
Primary Ingredients
Sildenafil
Phosphodiesterase type 5 (PDE5) inhibitor for treatment of erectile dysfunction
Adequate per single capsule
Sildenafil enhances nitric oxide-mediated vasodilation in penile tissue during sexual stimulation, promoting increased blood flow and erection. It is rapidly absorbed, with peak plasma concentrations reached within 30–120 minutes.
Practical Recommendations
- Use Only Under Medical Supervision: Consult a healthcare provider before using SIDEGRA, especially if you have heart disease, liver or kidney problems, or are taking other medications such as nitrates or alpha-blockers.
- Avoid Alcohol And Grapefruit: Alcohol may increase the risk of side effects like dizziness, while grapefruit juice can alter sildenafil metabolism and increase blood levels unpredictably.
- Do Not Combine With Other ED Products: Avoid using other erectile dysfunction treatments or 'male enhancement' supplements, as they may contain hidden PDE5 inhibitors that could lead to overdose.
Is it Safe?
Sildenafil is safe when prescribed appropriately but carries significant risks if used incorrectly. Concomitant use with nitrates can cause life-threatening hypotension. Unregulated products containing hidden sildenafil or its analogues pose additional dangers due to inconsistent dosing and unknown impurities.
Safety & Considerations
- Contraindication: Do not use with nitrates (e.g., nitroglycerin) or nitric oxide donors—risk of severe, potentially fatal hypotension.
- Drug Interaction: Use caution with alpha-blockers, antihypertensives, or CYP3A4 inhibitors (e.g., ketoconazole), which may increase sildenafil levels or enhance blood pressure-lowering effects.
- Medical Condition: Not recommended for individuals with recent stroke, unstable angina, severe liver impairment, or hereditary degenerative retinal disorders.
The Science
At 50 mg, sildenafil falls within the standard therapeutic range (25–100 mg) studied in clinical trials for erectile dysfunction. This dose is effective for most men and is often the starting point in treatment regimens.
Found unlisted PDE-5 inhibitors, including sildenafil, in 23 of 71 herbal sexual enhancement supplements, highlighting public health risks of unlabeled pharmaceuticals.
Detected 68 mg of total sildenafil-related compounds, including unreported derivatives, in an alleged herbal supplement, indicating deliberate adulteration.
Identified dichlorodenafil, an unapproved and potentially toxic sildenafil analogue, in dietary supplements, prompting need for improved detection standards.
Discovered mutaprodenafil, a novel unregulated sildenafil analogue, in a supplement and confirmed its structure via synthesis, showing emergence of new adulterants.
See grades while you shop
Get instant supplement ratings directly on iHerb. Amazon & more coming soon.
Works on iHerb now, Amazon & more coming soon
Stay updated on supplement research
Get newsletters about the latest developments in supplements and evidence-based insights.
No spam. Unsubscribe anytime.
Want another product analyzed?
Scan any supplement label for a free analysis