Overview
Acacetin is a flavonoid found in various plants, including Acacia mearnsii, and has been studied for its potential anti-inflammatory, antioxidant, and chemopreventive properties. Preclinical studies suggest acacetin may exert chemopreventive effects through modulation of drug-metabolizing enzymes and scavenging of reactive oxygen species, supporting its role as a blocking agent in carcinogenesis [1][2]. It may also influence signal transduction pathways involved in cell proliferation and apoptosis, indicating potential suppressing activity in later stages of tumor development [1]. While direct human clinical trials on acacetin are limited, related flavonoid-rich extracts, such as those from Acacia mearnsii used in ACAPOLIA® products, have been consumed safely in Japan as part of health foods, with established safety profiles based on long-term use and clinical testing [3]. However, specific dosing, efficacy, and safety data for isolated acacetin in humans remain insufficient.
Dosage Guide
Upper Intake Limit
Maximum safe daily intake
Clinical Notes
- No established RDA or therapeutic dosage for acacetin due to insufficient human clinical data.
- Potential interactions with cytochrome P450 enzymes due to flavonoid activity; monitor if used with medications metabolized by CYP3A4 or CYP2C9.
- Safety during pregnancy, lactation, or in pediatric populations has not been established.
Research
Acacetin may act as a chemopreventive agent by blocking carcinogenesis initiation via antioxidant effects and modulation of drug-metabolizing enzymes.
Natural flavonoids like acacetin show chemopreventive potential in preclinical models with minimal toxicity, supporting their role in cancer prevention strategies.
Flavonoid-rich bark extract from *Acacia mearnsii*, containing compounds like acacetin, has a history of safe use in dietary supplements in Japan.
