Amino Plus Blend - Supplement Ingredient Research

Overview

The Amino Plus Blend appears to refer to a multi-amino acid formulation, potentially designed for use in metabolic disorders such as phenylketonuria (PKU) or for supporting protein metabolism in malnutrition or aging. In PKU, phenylalanine-free amino acid mixtures are essential to meet protein requirements while restricting natural protein intake, and tablet-based formulations have been shown to be a practical and acceptable alternative to liquid protein substitutes, improving adherence in some patients [1]. Aromatic amino acid (AAA) supplementation, including phenylalanine and tyrosine, has demonstrated benefits in enhancing whole-body protein synthesis in children with severe acute malnutrition during recovery, suggesting a potential role in catabolic or undernourished states [7]. However, evidence for additional leucine co-ingestion in elderly adults shows no further augmentation of post-exercise muscle protein synthesis beyond protein and carbohydrate intake alone, challenging the benefit of isolated branched-chain amino acid supplementation in aging muscle [2]. Overall, amino acid blends are most effective when tailored to specific metabolic needs, such as in inborn errors of metabolism or malnutrition, rather than as general supplements in healthy individuals.

Dosage Guide

Recommended Daily Allowance

For generally healthy individuals

Children with PKUIndividualized based on age, weight, and metabolic needs(Typically 1.5–3 g protein equivalent/kg/day from amino acid mixture)

Adults with PKUIndividualized(Minimum 40% of protein substitute intake may be provided via tablets)

Therapeutic Doses

For treatment of specific conditions

Severe acute malnutrition (children)330 mg/kg/day aromatic amino acidsAs phenylalanine and tyrosine during catch-up phase

PKU managementAs directed by metabolic specialistPhenylalanine-free amino acid blend in liquid, powder, or tablet form

Upper Intake Limit

Maximum safe daily intake

mg— No established UL for amino acid blends; dosing must be individualized and monitored in metabolic disorders

Special Forms

Alternative forms for specific needs

Phenylalanine-free amino acid tablets

PKU management, improved adherence over liquids

Glycomacropeptide (cGMP)-based protein substitute

Alternative protein source in PKU with better palatability

Clinical Notes

Amino acid blends for PKU must be phenylalanine-free and used under medical supervision.
In malnutrition, AAA supplementation may support protein anabolism but should be part of a complete nutritional rehabilitation plan.
Leucine supplementation does not provide additional benefit for muscle synthesis in elderly when adequate protein is consumed.
Always verify the amino acid profile and purity of supplements, as formulations vary widely [6].
Monitor blood amino acid levels and metabolic markers regularly in patients on long-term amino acid supplements.

Research

Key FindingsPubMed

Amino acid tablets are a practical and acceptable alternative to liquid protein substitutes in PKU patients, improving compliance.

Are tablets a practical source of protein substitute in phenylketonuria?

Archives of disease in childhood•2003

Adding free leucine to protein and carbohydrate after exercise does not further increase muscle protein synthesis in elderly men.

Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men.

The British journal of nutrition•2008

Single amino acid supplementation in aminoacidopathies is used for specific therapeutic goals, but evidence is limited and context-dependent.

Single amino acid supplementation in aminoacidopathies: a systematic review.

Orphanet journal of rare diseases•2014

Glycomacropeptide-based protein substitutes are palatable and well-tolerated alternatives to amino acid-based formulas in PKU.

Evaluation of a New Glycomacropeptide-Based Protein Substitute in Powdered and Liquid Format in Patients with PKU.

Nutrients•2023

Supplementing specific amino acid combinations (e.g., Lys, Met, Thr, Pro, Gly) in calves improves growth performance, suggesting potential for targeted amino acid formulation.

Using compositional mixed-effects models to evaluate responses to amino acid supplementation in milk replacers for calves.

Journal of dairy science•2021

Clarity on supplement form, dose, delivery, and population is critical to avoid misinterpretation and potential harm.

Supplements: questions to ask to reduce confusion.

The American journal of clinical nutrition•2000

Aromatic amino acid supplementation increases whole-body protein synthesis in children during recovery from severe acute malnutrition.

Dietary supplementation with aromatic amino acids increases protein synthesis in children with severe acute malnutrition.

The Journal of nutrition•2014

Estimating amino acid intake from supplements is challenging due to variability in formulations and lack of standardized reporting.

Approaches to assessment of exposure to food- and supplement-derived amino acids.

The Journal of nutrition•2004

Products Containing Amino Plus Blend(1 report)

CREATINE X3

SIXSTAR

B+

You get: 160 mgGoal: 330 mg/kg/day (for aromatic amino acids in malnutrition)

CREATINE X3 is a performance-focused dietary supplement centered on creatine monohydrate, the most researched and effective form of creatine for enhancing high-intensity exercise capacity. With a clinically effective dose of 3,000 mg per serving, it supports increased strength, power output, and lean mass gains when combined with resistance training.