CREATINE X3 Audit Report

CREATINE X3 by SIXSTAR is formulated to deliver a targeted dose of creatine monohydrate, the gold-standard ingredient for improving anaerobic performance and muscle adaptation. Creatine monohydrate is extensively supported by clinical evidence, with over two decades of research confirming its role in increasing intramuscular phosphocreatine stores, accelerating ATP regeneration during short bursts of intense activity, and promoting gains in strength and fat-free mass across diverse populations [1][2]. The 3,000 mg dose aligns with standard maintenance protocols and is sufficient to maintain saturation in most individuals without requiring a loading phase.

While the product includes trace amounts of sodium and minimal carbohydrate, these contribute negligibly to performance outcomes. The Amino Plus Blend is present in a very low quantity (160 mg), far below therapeutic thresholds for any specific amino acid effect. Other compounds such as glycine, L-arginine, L-methionine, carnosine, and alpha-lipoic acid are listed as 'undetected,' indicating they are either absent or present in insignificant amounts. As such, the efficacy of CREATINE X3 rests almost entirely on its creatine monohydrate content, making it a straightforward, single-ingredient performance supplement despite the branding suggesting a multi-component formula.

In this report

Quick Summary

Transparency95

High transparency: all ingredients are disclosed with exact amounts for creatine, sodium, and carbohydrates. The 'undetected' labeling for several ingredients is unusual but honest. No proprietary blend obscures dosing.

Efficacy80

High efficacy for its primary purpose—delivering creatine monohydrate at a clinically effective dose (3,000 mg). The product performs well as a single-ingredient creatine supplement, though the 'X3' branding may mislead consumers into expecting multi-component synergy that is not supported by ingredient levels.

Bioavailability90

Creatine monohydrate is the most bioavailable and well-absorbed form of creatine, with no need for enhanced delivery systems. The formulation uses the optimal compound for efficacy and absorption.

Safety95

Excellent safety profile. Creatine monohydrate is safe for long-term use in healthy individuals. The low sodium and absence of stimulants or high-dose additives reduce risk. No interactions expected at these doses.

Suggested: 1 serving/day to reach clinical midpoint

Why Take This Product

CREATINE X3 should be taken primarily to support improvements in high-intensity exercise performance, including weightlifting, sprinting, and interval training. The 3,000 mg dose of creatine monohydrate helps maintain elevated muscle creatine stores, which enhances energy availability during short-duration, maximal-effort activities. This can translate into increased training volume, faster recovery between sets, and greater long-term gains in strength and lean muscle mass when combined with resistance exercise. It is particularly beneficial for athletes and fitness enthusiasts seeking a scientifically validated, no-frills creatine supplement without proprietary blends or unnecessary additives.

Key Benefits

Enhanced Exercise Performance: Creatine monohydrate increases phosphocreatine availability in muscle, enabling faster ATP regeneration during high-intensity efforts such as weightlifting and sprinting [1][2]. This leads to improved power output and work capacity over repeated bouts of exercise.
Increased Muscle Strength and Lean Mass: Long-term creatine supplementation (3–5 g/day) combined with resistance training consistently increases muscle strength and fat-free mass in both men and women [18][19]. These adaptations are especially noticeable during the initial phases of training.
Improved Recovery and Injury Resilience: Emerging evidence suggests creatine may reduce muscle damage and inflammation post-exercise, supporting faster recovery. It may also enhance cellular hydration and reduce cramping or injury risk during intense training [2].
Neuroprotective and Cognitive Support: Creatine plays a role in brain energy metabolism, and supplementation has shown potential benefits in cognitive performance under stress, sleep deprivation, or during aging, though more research is needed in healthy adults [2].
Safe and Well-Tolerated Long-Term Use: Creatine monohydrate has an excellent safety profile across short- and long-term use in healthy individuals, with no clinically significant adverse effects on kidney, liver, or cardiac function [3][2].

Who Should Take This

CREATINE X3 is ideal for athletes, bodybuilders, and active individuals engaged in resistance or high-intensity interval training who want to improve strength, power, and muscle mass. It is also suitable for older adults looking to combat age-related muscle loss (sarcopenia) and for female athletes, as creatine is equally effective and safe in women [19]. Individuals with neuromuscular disorders or cognitive concerns may also benefit, though consultation with a healthcare provider is advised in clinical populations.

Potential Side Effects

The most common side effect is transient water retention in the early stages of supplementation, which may lead to a slight increase in body weight. This is not harmful and typically resolves with continued use. Gastrointestinal discomfort may occur at higher doses (>5 g per serving), but the 3,000 mg dose in CREATINE X3 minimizes this risk. There is no credible evidence of kidney damage in healthy individuals, though those with pre-existing renal disease should avoid creatine or use under medical supervision. No serious adverse events have been reported in long-term studies.

Ingredient Breakdown

The formulation of CREATINE X3 is dominated by creatine monohydrate, the only ingredient present at a clinically relevant dose. All other components—such as the Amino Plus Blend, sodium, and trace carbohydrates—are present in amounts too low to exert meaningful physiological effects. Compounds like glycine, L-arginine, and carnosine are listed as undetected, suggesting they are either not included or below detectable levels.

Primary Ingredients

Creatine Monohydrate

Increases phosphocreatine stores for ATP regeneration during high-intensity exercise

3,000 mg

per capsuleGoal: 3,000-5,000 mg

Dose of 3,000 mg/day is within the standard maintenance range (3–5 g/day) and sufficient to maintain muscle saturation in most individuals without loading [1]. No superior efficacy has been shown for alternative forms like creatine ethyl ester [20].

Creatine monohydrate is the most effective, well-researched, and cost-efficient form of creatine. It enhances short-duration, high-intensity performance and supports muscle strength and lean mass gains when combined with resistance training [1][2]. Long-term use is safe in healthy individuals, with no adverse effects on kidney or liver function [3][2].

Supporting Ingredients

There are 9 supporting ingredients.

Other ingredients (Microcrystalline Cellulose, Dicalcium Phosphate, Croscarmellose Sodium, Stearic Acid, Polyethylene Glycol, Talc, Polysorbate 80, Magnesium Stearate, Silica and Acesulfame Potassium) are inactive ingredients used for capsule manufacturing, stability, or flow and are not analyzed in this report.

Practical Recommendations

Take Consistently With Or Without Food: Creatine monohydrate is effective whether taken with carbohydrates/protein or alone. For optimal adherence, take 1 serving (3,000 mg) daily at any time of day.
Consider A Loading Phase For Faster Saturation: To rapidly saturate muscles, take 20 g/day (split into 4 doses) for 5–7 days, followed by the maintenance dose of 3,000 mg/day [1].
Stay Hydrated: Due to creatine’s cell-hydrating effects, ensure adequate daily fluid intake to support performance and comfort.
Combine With Resistance Training: Maximize benefits by using creatine alongside a structured strength or power training program.

Is it Safe?

Creatine monohydrate is one of the most thoroughly studied supplements in sports nutrition, with an outstanding safety record. The low sodium content (25 mg) poses no cardiovascular concern, and the absence of stimulants or high-dose additives further enhances safety. However, individuals with severe renal impairment should avoid use, and those on medications affecting renal function should consult a healthcare provider.

Safety & Considerations

Renal Function: Avoid in individuals with severe renal impairment; consult a healthcare provider if you have kidney disease.
Hydration: Ensure adequate fluid intake due to creatine’s cell-hydrating effects.

The Science

Efficacy is determined primarily by the presence and dose of creatine monohydrate, which is the most bioavailable and well-researched form. At 3,000 mg per serving, CREATINE X3 delivers a dose supported by clinical evidence for maintaining muscle saturation and enhancing performance. While the product name implies a multi-ingredient 'X3' formula, no other active ingredients are present in effective amounts, limiting synergistic potential.

References (75)PubMed / NIH

Creatine supplementation (0.3 g/kg/day loading, 0.03 g/kg/day maintenance) enhances high-intensity exercise performance.

Creatine supplementation.

Current sports medicine reports•2013

Creatine is safe and effective for improving performance and lean mass in healthy individuals and patient populations.

Creatine Supplementation: An Update.

Current sports medicine reports•2021

No clinically significant changes in renal, hepatic, or muscle function with creatine supplementation.

Safety of creatine supplementation.

Sub-cellular biochemistry•2007

Adding leucine to protein and carbs does not further increase muscle protein synthesis in elderly men.

Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men.

The British journal of nutrition•2008

Sodium intake increases blood pressure, while potassium lowers it in (pre)hypertensive adults.

Effects of sodium and potassium supplementation on blood pressure and arterial stiffness: a fully controlled dietary intervention study.

Journal of human hypertension•2015

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