Overview
Hydrolyzed marine collagen peptides are bioactive proteins derived from fish collagen that are enzymatically broken down into low-molecular-weight peptides for enhanced absorption. Clinical evidence supports their role in improving skin health and joint function. Oral supplementation has been shown to significantly improve skin hydration, elasticity, and dermal density, with benefits observed as early as 6 weeks and increasing through 12 weeks of daily intake [5][3][7]. These effects are attributed to the stimulation of fibroblast activity and increased synthesis of extracellular matrix components like collagen and proteoglycans. For joint health, collagen peptides demonstrate analgesic and anti-inflammatory properties, reducing pain and stiffness in individuals with osteoarthritis or activity-related joint discomfort [1][2][4]. The Gly-Pro-Hyp tripeptide motif, abundant in hydrolyzed collagen, is believed to play a key role in tissue targeting and bioactivity. Benefits appear dose-dependent and more pronounced in individuals with existing joint or skin concerns.
Dosage Guide
Therapeutic Doses
For treatment of specific conditions
Special Forms
Alternative forms for specific needs
Enhanced absorption; rich in Gly-Pro-Hyp tripeptide for skin benefits
Clinically studied formulations for joint and skin health
Clinical Notes
- Effects are more pronounced in individuals with existing joint discomfort or skin aging signs.
- Consistent daily intake is required for benefits, with effects typically emerging after 4–8 weeks.
- Marine collagen is suitable for pescatarians but not for individuals with fish allergies.
- No serious adverse effects reported across studies; well-tolerated in long-term use up to 6 months.
Research
Oral collagen peptides from pork or bovine sources significantly reduced WOMAC and VAS scores in knee osteoarthritis patients over 13 weeks.
Daily oral supplementation with hydrolyzed fish collagen plus vitamins improved skin elasticity and joint well-being over 90 days in a placebo-controlled trial.
10 g/day of collagen peptides for 12 weeks reduced knee pain in healthy active adults with self-reported knee pain compared to placebo.
Hydrolyzed chicken collagen type II improved joint pain, stiffness, and mobility on WOMAC scores after 8 weeks in adults with joint discomfort.
1,000 mg/day of low-molecular-weight collagen peptide significantly improved skin hydration and elasticity after 6 and 12 weeks.
2.5 g/day of bioactive collagen peptides reduced cellulite severity and improved dermal density in normal-weight women over 6 months.
2.5 g and 5.0 g daily doses of collagen hydrolysate improved skin elasticity and moisture in women aged 35–55 over 8 weeks.
1,200 mg/day of collagen hydrolysate for 6 months increased clinical response rate (≥20% VAS improvement) in patients with joint pain.
Products Containing Hydrolyzed Marine Collagen Peptides(2 reports)
CollagenUP® is a marine collagen peptide supplement designed to support skin and joint health. The primary ingredient, hydrolyzed marine collagen peptides (5 g per serving), is supported by hyaluronic acid and vitamin C to enhance collagen synthesis and tissue hydration. While the collagen dose is below typical clinical levels, it is formulated for daily use as part of a broader nutritional strategy.
This supplement is formulated around hydrolyzed marine collagen peptides as the primary active ingredient, supported by a prebiotic fiber blend and a leucine-enriched essential amino acid complex. The product targets skin and joint health, gut function, and muscle protein synthesis support. While the collagen dose is clinically relevant, the amino acid and prebiotic components serve as functional adjuncts.