Overview
Leucoselect phytosome is a standardized grape seed procyanidin extract complexed with soy phospholipids to enhance bioavailability. It has been studied primarily for its antioxidant, anti-inflammatory, and potential chemopreventive properties. Preclinical and early clinical evidence suggests that Leucoselect may modulate pathways involved in carcinogenesis, including reducing cellular proliferation and oxidative stress. In a pilot study involving heavy smokers, Leucoselect phytosome was administered for 3 months and showed acceptable safety and potential biological activity in lung tissue, with trends toward reduced Ki-67 labeling index, a marker of cell proliferation [3]. Grape seed extracts, including Leucoselect, are rich in flavonoids and procyanidins, which contribute to vascular protection by improving endothelial function and reducing oxidative damage, suggesting potential cardiovascular benefits [2][7]. These mechanisms support its use as a dietary supplement for antioxidant support and possible cancer chemoprevention, though larger clinical trials are needed to confirm efficacy.
Dosage Guide
Therapeutic Doses
For treatment of specific conditions
Special Forms
Alternative forms for specific needs
Enhanced bioavailability formulation using soy phospholipids; preferred for clinical use
Clinical Notes
- Generally well-tolerated; mild gastrointestinal symptoms reported in some individuals.
- Potential interaction with drugs metabolized by CYP450 enzymes due to flavonoid content; caution with anticoagulants, antiplatelets, and chemotherapy agents.
- Lack of long-term safety data; not recommended during pregnancy or lactation without medical supervision.
- Monitor for bleeding risk when used with anticoagulant or antiplatelet drugs due to potential inhibition of platelet aggregation.
Research
Grape seed extract shows anticancer and chemopreventive potential in preclinical models across various cancer types.
Flavonoid-rich grape seed extracts may benefit high cardiovascular risk patients by improving endothelial function and reducing oxidative stress and inflammation.
Leucoselect phytosome was safe and well-tolerated at doses up to 600 mg/day over 3 months in smokers, with preliminary evidence of reduced bronchial cell proliferation.
Grapefruit compounds, including flavonoids, show antitumor activity, though this study is not directly on grape seed extract.
Muscadine grape extract was tested in advanced cancer patients, showing safety and potential anti-inflammatory effects, though not specific to Leucoselect.
Red vine leaf extract (related to grape polyphenols) improved symptoms in chronic venous insufficiency, suggesting vascular benefits of grape-derived flavonoids.
Grape polyphenols exhibit antioxidant effects, protect against LDL oxidation, and support endothelial function, with potential neuroprotective effects.
Combination chemoprevention using grape antioxidants like resveratrol, quercetin, and procyanidins shows synergistic potential against cancer development.
