Overview
Ashwagandha (Withania somnifera), also known as Indian ginseng, is an adaptogenic herb traditionally used in Ayurvedic medicine for its neuroprotective, anti-inflammatory, and immunomodulatory properties. Clinical and preclinical studies suggest that Ashwagandha may help reduce stress and anxiety, with a 2022 meta-analysis of 12 randomized controlled trials (n=1,002) showing a significant reduction in stress and anxiety scores with supplementation [1]. It has demonstrated neuroprotective effects by protecting brain-derived cells against oxidative stress and promoting neuronal differentiation in vitro [3]. Additionally, Ashwagandha exhibits anti-arthritic potential, supported by analysis of 77 registered clinical trials in India, many of which are placebo-controlled and focused on inflammatory joint conditions [2]. Immunomodulatory effects include activation of CD4+ T cells and natural killer (NK) cells after short-term use [4]. The bioactive compound withaferin A shows promising preclinical anti-cancer activity, particularly in B-cell lymphoma, via inhibition of NF-κB signaling and induction of oxidative stress in tumor cells [5][6].
Dosage Guide
Therapeutic Doses
For treatment of specific conditions
Special Forms
Alternative forms for specific needs
Most studied form; high concentration of withanolides, used for stress, cognition, and vitality
Lower dose required; used in stress and metabolic health studies
Experimental form; used in preclinical cancer research, not widely available in supplements
Clinical Notes
- Generally well-tolerated, but high doses may cause gastrointestinal upset or drowsiness
- Potential interaction with immunosuppressants, sedatives, thyroid hormones, and antidiabetic drugs
- Avoid in pregnancy due to possible uterine stimulation; limited safety data
- Monitor thyroid function in individuals with thyroid disorders as Ashwagandha may increase T4 levels
- Long-term safety beyond 3 months not well established in clinical trials
Research
Meta-analysis shows Ashwagandha significantly reduces anxiety and stress in adults
Analysis of 77 clinical trials supports anti-arthritic potential of Ashwagandha
Withaferin A inhibits B-cell lymphoma growth and NF-κB signaling in preclinical models
Ashwagandha extract activates CD4+ T cells and NK cells in humans after 96 hours
Leaf extracts protect neural cells from oxidative stress and induce differentiation
Withaferin A is a key bioactive compound with preclinical anti-cancer and anti-inflammatory effects
Review highlights neuropharmacological benefits of Ashwagandha in neurodegenerative diseases
Products Containing Ashwagandha(2 reports)
This supplement is centered on shilajit, a traditional Ayurvedic substance with potential adaptogenic and mitochondrial-supporting properties. The 1000 mg dose of shilajit is at the upper limit of clinically studied ranges, suggesting a focus on energy, cognitive, and fatigue support. Other ingredients are included in much lower amounts and likely serve supportive roles.
PRIME TEST PRO TESTOSTERONE BOOSTER is a dietary supplement formulated to support healthy testosterone levels, primarily through clinically relevant doses of Ashwagandha and Fenugreek, two botanicals with emerging evidence for endocrine modulation. The inclusion of supportive nutrients like Vitamin D3, Zinc, and Magnesium—key players in hormonal and metabolic health—further aligns the formula with evidence-based strategies for optimizing male vitality.