Overview
Grape extract, particularly from seeds and skins, is rich in polyphenolic compounds such as proanthocyanidins, catechins, and resveratrol, which contribute to its potent antioxidant and anti-inflammatory properties [1][2]. These bioactive components help reduce oxidative stress, improve endothelial function, and modulate lipid metabolism, supporting cardiovascular health. Clinical evidence indicates that grape seed extract (GSE) supplementation significantly reduces diastolic blood pressure and heart rate, suggesting a beneficial role in managing cardiovascular risk factors [2]. Additionally, GSE shows potential neuroprotective effects and may support gastrointestinal health, although its impact on glucose metabolism remains inconclusive [1][6]. Despite mixed findings on oxidative stress biomarkers, some meta-analyses report increased total antioxidant capacity with grape product intake [7][8].
Dosage Guide
Therapeutic Doses
For treatment of specific conditions
Upper Intake Limit
Maximum safe daily intake
2500 mg— Up to 2500 mg/day considered safe for up to 4 weeks; long-term safety not established
Special Forms
Alternative forms for specific needs
Preferred form for cardiovascular and antioxidant benefits
For neuroprotection and metabolic support
Clinical Notes
- High-dose grape seed extract may reduce iron absorption; monitor in individuals with iron deficiency [5]
- Potential interactions with anticoagulants due to antiplatelet effects of polyphenols
- Obesity may alter polyphenol metabolism, potentially affecting efficacy [4]
- Long-term safety beyond 4 weeks not well established; use under supervision at high doses
Research
Grape seed and skin extract improves lipid metabolism and reduces oxidative stress with anti-inflammatory and antiapoptotic effects.
Grape seed extract significantly reduces diastolic blood pressure and heart rate in adults.
Grape polyphenols support endothelial function, increase antioxidant capacity, and offer neuroprotection.
Obese individuals may have altered pharmacokinetics of grape polyphenols, affecting absorption and metabolism.
Proanthocyanidin-rich grape seed extract at doses up to 2500 mg/day for 4 weeks is safe and well-tolerated in healthy adults.
Acute intake of grape/pomegranate pomace supplement did not improve glucose metabolism or oxidative stress markers in adults with abdominal obesity.
Grape seed extract supplementation shows mixed effects on oxidative stress and inflammation biomarkers in meta-analysis.
Grape products containing polyphenols significantly increase total antioxidant capacity in randomized clinical trials.
