Muscle Builder by MuscleTech is a performance-focused dietary supplement designed to support strength, power output, and training capacity in active individuals. The product centers on Adenosine 5'-Triphosphate Disodium (ATP), the disodium salt of ATP, formulated in a stabilized oral delivery system (Peak ATP®) to resist gastrointestinal degradation. This ingredient is the cornerstone of the product’s mechanism, with clinical evidence supporting its role in improving resistance exercise performance when taken acutely at 400 mg.
Research indicates that oral ATP does not need to be absorbed intact to exert physiological effects; instead, it may act through purinergic receptors in the gut and vasculature, influencing blood flow, neuromuscular activation, and fatigue resistance. While systemic absorption of intact ATP is limited, the extracellular signaling effects appear sufficient to enhance performance in trained individuals during high-intensity exercise. Muscle Builder delivers this ingredient at the precise dose used in key clinical trials, positioning it as a targeted, evidence-based option for athletes and fitness enthusiasts seeking acute performance benefits.
Quick Summary
Full transparency is demonstrated with all ingredient amounts disclosed and no proprietary blends used, allowing for accurate assessment of dosing and efficacy.
The primary ingredient is dosed at 400 mg, matching the clinically effective dose shown to improve resistance exercise performance in trained individuals [1][2], resulting in a high efficacy score despite lack of data on supporting ingredients.
The use of Peak ATP®, a stabilized form of oral ATP disodium, provides enhanced bioavailability through resistance to GI degradation and extracellular receptor activation, warranting a high bioavailability score.
Short-term use appears safe based on clinical trials, but long-term safety data are limited. Potential interactions with anticoagulants exist due to adenosine's effects on platelets and vascular tone.
Suggested: 1 serving/day to reach clinical midpoint
Why Take This Product
Key Benefits
- Improved Resistance Exercise Performance: A single 400 mg dose of oral ATP significantly increased the number of repetitions performed during lower-body resistance training in recreationally trained males [1].
- Enhanced Power Output: Acute supplementation with 400 mg ATP improved peak and mean power during resistance exercise in trained adults in a placebo-controlled crossover study [2].
- Support for Cellular Energy Signaling: Beyond direct energy provision, ATP acts as an extracellular signaling molecule that modulates metabolic and vascular responses relevant to exercise [7].
- Potential for Acute Use Before Training: The benefits are observed with acute dosing, making it suitable for pre-workout use without requiring chronic loading [1].
Who Should Take This
Potential Side Effects
Ingredient Breakdown
The formulation relies primarily on Adenosine 5'-Triphosphate Disodium, a stabilized form of ATP designed for oral delivery. While other ingredients may be present, ATP is the only one with a disclosed clinical dose and direct evidence supporting the product’s claims.
Primary Ingredients
Adenosine 5'-Triphosphate Disodium
Exercise performance, energy signaling
The ingredient is provided at the clinically validated dose of 400 mg, used in multiple human trials demonstrating improved muscular performance. It is classified as primary due to its presence in the product name context (muscle building), dominant dose, and direct link to claimed benefits.
Stabilized oral ATP (Peak ATP®) shown to improve resistance exercise performance via extracellular purinergic signaling. Dosed at 400 mg, matching clinical studies.
Practical Recommendations
- Take 30 Minutes Before Resistance Training: For optimal performance benefits, consume one serving 30 minutes prior to exercise, as studied in clinical trials [1].
- Use In Cycles: Given limited long-term safety data, consider using Muscle Builder in 8-12 week cycles with breaks to assess tolerance and maintain sensitivity.
- Combine With A Balanced Diet And Training Program: Maximize results by pairing supplementation with adequate protein intake, progressive overload, and recovery strategies.
Is it Safe?
The primary ingredient has demonstrated short-term safety in clinical trials, but long-term supplementation has not been extensively studied. Caution is advised for individuals on blood-thinning medications due to potential interactions with purinergic signaling pathways.
Safety & Considerations
- Drug Interaction: May interact with anticoagulant or antiplatelet drugs due to adenosine-mediated effects on platelet aggregation and vasodilation.
- Long Term Use: Safety of chronic ATP supplementation has not been extensively evaluated; intermittent use is recommended.
Reports for Similar Products
The Science
Efficacy is driven by the presence of Adenosine 5'-Triphosphate Disodium at 400 mg per serving—the exact dose shown in multiple studies to enhance resistance exercise performance. The mechanism likely involves extracellular signaling rather than systemic ATP absorption, aligning with current understanding of oral ATP bioactivity.
A single 400 mg dose of oral ATP improved performance and physiological response during lower-body resistance exercise in recreationally trained males.
Acute 400 mg ATP supplementation enhanced muscular performance in trained adults during resistance exercise in a placebo-controlled crossover study.
AMPK, activated by changes in AMP/ATP ratio, plays a key role in cellular energy homeostasis; declining AMPK activity with age may affect metabolic health.
Phosphorus, a key component of ATP, when supplemented at 500 mg, improved diet-induced thermogenesis in overweight and obese adults.
Creatine supplementation increases skeletal muscle phosphocreatine stores, supporting ATP regeneration during high-intensity exercise.
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