The WELBUDA MAGNESIUM L-THREONATE L-THEANINE APIGENIN formula is designed as a cognitive and metabolic support supplement, leveraging three bioactive compounds with distinct but complementary mechanisms. Magnesium L-threonate is a specialized form of magnesium known for its ability to cross the blood-brain barrier and elevate brain magnesium levels, supporting synaptic plasticity and cognitive performance. Clinical studies suggest that magnesium supplementation, particularly in deficient individuals, can improve metabolic parameters and blood pressure, with benefits most pronounced in those with baseline insufficiency [1][2]. At 150 mg per serving, the magnesium dose is below typical therapeutic ranges but may still contribute meaningfully when combined with dietary intake.
L-Theanine, included at 200 mg, is a well-researched amino acid that promotes relaxation without sedation by increasing alpha brain wave activity. It has demonstrated efficacy in reducing stress, improving sleep onset, and enhancing attention—especially in combination with caffeine [3][4]. Apigenin (50 mg) adds a flavonoid component with preclinical evidence for neuroprotection and anti-inflammatory activity, though robust human trials are lacking [5]. As a supplement, this product emphasizes brain health and stress resilience, with primary focus on magnesium and L-theanine as the key drivers of efficacy.
Quick Summary
All ingredient amounts are clearly disclosed with no proprietary blends, allowing full transparency into dosing and enabling informed evaluation of clinical relevance.
Efficacy is strong for primary ingredients: L-theanine at a full clinical dose (200 mg) and magnesium L-threonate at a moderate dose (150 mg) with high bioavailability. Benefits are well-supported for cognitive and stress support, though metabolic effects may be limited by lower magnesium dose.
The use of magnesium L-threonate—a high-bioavailability form with enhanced brain penetration—and pure L-theanine (likely Suntheanine®) significantly improves absorption and functional impact, warranting a high bioavailability score.
The product is generally safe at recommended doses, though magnesium requires caution in renal impairment, and apigenin lacks long-term safety data. Potential interactions with CNS depressants and antibiotics are noted.
Suggested: 2 servings/day to reach clinical midpoint
Why Take This Product
Key Benefits
Who Should Take This
Potential Side Effects
Ingredient Breakdown
Each ingredient in this formula plays a distinct role: magnesium supports enzymatic, neurological, and metabolic functions; L-theanine promotes calm focus and sleep quality; apigenin contributes antioxidant activity. The formulation appears to prioritize brain health and stress resilience, with magnesium and L-theanine as the primary active components.
Primary Ingredients
Magnesium
Essential mineral for enzymatic reactions, neurological function, and cardiovascular health
Dose is 37% of clinical midpoint (355 mg). High-absorption L-threonate form used, which may enhance brain delivery and functional impact despite lower dose.
Magnesium is involved in over 300 enzymatic processes, including blood pressure regulation, glucose metabolism, and synaptic plasticity. Supplementation has been shown to reduce blood pressure, particularly in those with baseline hypertension or low magnesium levels [1][2]. The L-threonate form is notable for its ability to cross the blood-brain barrier and elevate brain magnesium, supporting cognitive function. While the 150 mg dose is below typical therapeutic ranges (300–410 mg), the high bioavailability of L-threonate may partially compensate. Benefits are most consistent in magnesium-deficient populations.
L-Theanine
Promotes relaxation, improves focus, and supports sleep quality
Dose meets upper end of clinical range (100–200 mg). Well-supported by RCTs for stress, focus, and sleep.
L-theanine is a non-proteinogenic amino acid that increases alpha brain wave activity, promoting a state of calm alertness. It has been shown to reduce anxiety, improve attention, and enhance sleep quality without causing sedation [3][4]. At 200 mg, this dose falls within the upper end of the therapeutic range for anxiety and cognitive support and aligns with doses used in clinical trials. It is particularly effective when taken before stressful tasks or at bedtime for sleep onset. Suntheanine® or equivalent pure L-isomer is recommended for consistency.
Supporting Ingredients
There is 1 supporting ingredient.
Practical Recommendations
- Consider With Vitamin D: Magnesium is required for vitamin D activation; co-supplementation may enhance both metabolic and cardiovascular outcomes [8].
- Take In The Evening For Sleep Support: L-theanine’s effects on sleep onset and quality are best realized when taken before bedtime, especially in individuals with stress-related insomnia [4].
- Assess Magnesium Status: Benefits of magnesium are most evident in deficient individuals. Consider serum testing if metabolic or cardiovascular concerns are present.
Is it Safe?
The product contains ingredients with favorable safety profiles at the given doses. However, magnesium requires caution in renal impairment, and apigenin’s long-term safety at supplemental doses is not fully established. Potential interactions with medications, particularly CNS depressants and antibiotics, should be considered.
Safety & Considerations
- Renal Impairment: Avoid high-dose magnesium in individuals with severe kidney disease due to risk of hypermagnesemia.
- Drug Interaction: Magnesium may interfere with tetracyclines, fluoroquinolones, and bisphosphonates; separate dosing by 2–4 hours.
- Cns Depressants: L-theanine may enhance effects of sedatives; use caution when combining with CNS depressants.
- Apigenin Caution: Apigenin’s safety at long-term, high-dose supplementation is not established; potential for CYP450 interactions.
Reports for Similar Products
The Science
Efficacy is primarily driven by L-theanine at a clinically effective 200 mg dose and magnesium L-threonate at a moderate 150 mg. While the magnesium dose is below typical therapeutic ranges, the high bioavailability of the L-threonate form may enhance its impact. Apigenin adds theoretical benefit but lacks strong human evidence.
Meta-analysis: Magnesium supplementation (mean 410 mg/day) significantly reduces blood pressure, especially in deficient individuals.
400 mg/day magnesium improved blood pressure and metabolic profile in metabolic syndrome patients.
L-theanine induces alpha brain waves and has anxiolytic effects, supporting high-quality sleep initiation.
L-theanine significantly improves sleep onset latency and daytime dysfunction in a meta-analysis of RCTs.
Preclinical data support apigenin’s chemopreventive potential with few side effects in long-term animal studies.
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